P53 Mutation Cancer Cell Lines

Brain cancer cell lines.

P53 mutation cancer cell lines.

Bladder cancer cell lines. Several fundamental features of wild type and mutant proteins and their modifications are reviewed as well as animal models and clinical aspects such as recommendations for patient care. Analysis of p53 mutation status in human cancer cell lines. Colorectal cancer cell lines.

Cell lines by gene mutation tumor cell lines become more powerful tools for cancer research and drug discovery when the genetic abnormalities that drive their phenotype are known. Hct 116 cells contain wild type p53. Esophageal cancer cell lines. The colon cancer p53 hotspot mutation cell panel atcc no.

Human colon cancer cell lines with varied molecular characteristics eg. Berglind h 1 pawitan y kato s ishioka c soussi t. Knowledgebase and statistical tools for the analysis of tp53 gene mutations in human cancers. A special issue of human mutation has been released.

The id cards include cell line data such as cancer type and atcc number when available as well as some specific information on potential misidentifications changes of identity or shared origins. 1 karolinska institute department of oncology pathology cancer center karolinska cck stockholm. The nci 60 panel. Tcp 2020 is composed of six select cell lines derived from colon cancer.

Ht 29 caco 2 and sw480 contain mutated p53 were used as the panels in this study to. This special issue on tp53 propels the tp53 gene into the post genomic era. Atcc now offers our reliable authenticated tumor cell lines annotated with gene mutation infor mation from the sanger institute cosmic database. Epub 2008 may 11.

Since then a large number of publications have demonstrated many gofs in numerous cell lines with a variety of p53 mutations summarized in table 1 the gof acquired by mutant p53 is further supported by the finding that patients carrying a tp53 missense mutation leading to expression of a. This panel combines wild type p53 cell lines with mutant p53 cell lines that carry hotspot mutations in one of the following codons. The tp53 gene network in the post genomic era. Cell lines with a controversial p53 status.

Breast cancer cell lines. Our laboratory has two separate culture lines of the lncap human prostate cancer cells. One strain lncap gw had a mutation in one of two alleles at position 273 arg. The hanbook of p53 mutation in cell lines.

P53 gene structure and chromosome 17p alleles were studied in the three human prostate cancer cell lines lncap du 145 and pc 3. P53 mutations in cell lines. When the introduction of mutant p53 into p53 null cells was shown to give rise to a new phenotype.